Fig 1: Myelin protein and myelin inhibitor expression at day 62 p.i. Increased MBP(+) (A–C) and CNPase(+) cells (D–F) in WML of the cerebellums of Fgfr1ind-/- mice. Myelin protein PLP was upregulated in Fgfr1ind-/- mice (G,H). Myelin proteins CNPase and MBP (G,H), and myelin inhibitors SEMA3A, TGF-ß, LINGO-1 (I,J) were not regulated. Cerebellar tissue immunostaining: n = 3/group, cerebellar tissue lysate western blot: n = 3–4/group. Data are expressed as the mean ± SEM. ns = not significant, * p < 0.05, ** p < 0.01, *** p < 0.001.